Megakaryocyte

{
  "id": "MLC-T-CHM-007144",
  "term": "Megakaryocyte",
  "field": "Chemistry",
  "definition": "A large bone marrow cell responsible for producing platelets, which are necessary for normal blood clotting. These cells undergo a process called endomitosis, in which they replicate their DNA without dividing, resulting in a very large cell with a multi-lobed nucleus. Upon maturation, megakaryocytes extend cytoplasmic projections into blood sinusoids, and these projections fragment into thousands of platelets that are released into the circulation.",
  "subject": "Chemistry and Human Health",
  "see_also": [
    "bone marrow",
    "platelet"
  ],
  "references": [
    "PAC, 2012, 84, 1113. 'IUPAC glossary of terms used in immunotoxicology (IUPAC Recommendations 2012)' on page 1211 (https://doi.org/10.1351/PAC-REC-11-06-03)"
  ],
  "url": "https://mlchart.com/terminology/chemistry/megakaryocyte/"
}