NIH shift

{
  "id": "MLC-T-CHM-007942",
  "term": "NIH shift",
  "field": "Chemistry",
  "definition": "An intramolecular migration of a hydrogen atom or other substituent during the enzymatic hydroxylation of an aromatic ring. This rearrangement occurs when an arene oxide intermediate is formed, leading to the retention of a label (e.g., deuterium) at the site of hydroxylation. It was first observed at the National Institutes of Health (NIH).",
  "subject": "Organic and Biomolecular Chemistry",
  "see_also": [
    "deuterium",
    "intramolecular",
    "labelling",
    "migration"
  ],
  "references": [
    "PAC, 1994, 66, 1077. 'Glossary of terms used in physical organic chemistry (IUPAC Recommendations 1994)' on page 1145 (https://doi.org/10.1351/pac199466051077)"
  ],
  "url": "https://mlchart.com/terminology/chemistry/nih-shift/"
}