Nucleofuge

{
  "id": "MLC-T-CHM-008133",
  "term": "Nucleofuge",
  "field": "Chemistry",
  "definition": "A leaving group that departs from a substrate with the electron pair that formed the bond. The ability of a group to act as a nucleofuge, its nucleofugality, is related to the stability of the anion or neutral molecule it forms upon departure. Good nucleofuges are the conjugate bases of strong acids; for instance, iodide (I⁻) and tosylate (TsO⁻) are excellent nucleofuges, while hydroxide (OH⁻), the conjugate base of the weak acid water, is a poor one.",
  "subject": "Organic and Biomolecular Chemistry",
  "see_also": [
    "electrofuge",
    "hydrolysis",
    "leaving group",
    "nucleophile"
  ],
  "references": [
    "PAC, 1994, 66, 1077. 'Glossary of terms used in physical organic chemistry (IUPAC Recommendations 1994)' on page 1145 (https://doi.org/10.1351/pac199466051077)"
  ],
  "url": "https://mlchart.com/terminology/chemistry/nucleofuge/"
}