poly-Ig receptor

{
  "id": "MLC-T-CHM-009147",
  "term": "poly-Ig receptor",
  "field": "Chemistry",
  "definition": "A membrane glycoprotein on the basolateral surface of mucosal epithelial cells that carries polymeric antibodies, mainly dimeric IgA and pentameric IgM, across the cell to the lumen. It binds the J chain of these antibodies, ferries them through the cell by transcytosis, and is then cut by a protease at the apical surface. The released extracellular part, the secretory component, stays attached to the antibody, giving secretory IgA.",
  "subject": "Chemistry and Human Health",
  "see_also": [
    "joining chain",
    "immunoglobulin A",
    "immunoglobulin M",
    "mucosa"
  ],
  "references": [
    "PAC, 2012, 84, 1113. 'IUPAC glossary of terms used in immunotoxicology (IUPAC Recommendations 2012)' on page 1232 (https://doi.org/10.1351/PAC-REC-11-06-03)"
  ],
  "url": "https://mlchart.com/terminology/chemistry/poly-ig-receptor/"
}