Prozone effect

{
  "id": "MLC-T-CHM-009621",
  "term": "Prozone effect",
  "field": "Chemistry",
  "definition": "A phenomenon observed in immunological assays, such as agglutination or precipitation tests, where high concentrations of antibody or antigen lead to a false-negative result. This occurs because an excess of one reactant prevents the formation of a stable lattice structure required for visible reaction. Dilution of the sample can often resolve this issue.",
  "subject": "Chemistry and Human Health",
  "references": [
    "PAC, 2012, 84, 1113. 'IUPAC glossary of terms used in immunotoxicology (IUPAC Recommendations 2012)' on page 1237 (https://doi.org/10.1351/PAC-REC-11-06-03)"
  ],
  "url": "https://mlchart.com/terminology/chemistry/prozone-effect/"
}