Spectral skewing

{
  "id": "MLC-T-CHM-011151",
  "term": "Spectral skewing",
  "field": "Chemistry",
  "definition": "A distortion of the relative peak intensities in a mass spectrum that arises when the concentrations of the analytes entering the ion source change while the spectrum is being scanned, as when a chromatographic peak elutes into a scanning mass spectrometer. Ions measured at the start of the scan then come from a different composition than those measured at the end. Scanning faster, or using a time-of-flight analyzer that records all masses at once, reduces it.",
  "subject": "Analytical Chemistry",
  "references": [
    "PAC, 2013, 85, 1515. 'Definitions of terms relating to mass spectrometry (IUPAC Recommendations 2013)' on page 1591 (https://doi.org/10.1351/PAC-REC-06-04-06)"
  ],
  "url": "https://mlchart.com/terminology/chemistry/spectral-skewing/"
}