Surface-enhanced laser desorption/ionization

{
  "id": "MLC-T-CHM-011677",
  "term": "Surface-enhanced laser desorption/ionization",
  "field": "Chemistry",
  "definition": "An adaptation of matrix-assisted laser desorption/ionization in which the sample target is coated with chromatographic material, for example ion-exchange, hydrophobic or metal-affinity chemistry, so that only certain proteins or peptides from a mixture stay bound to it. The retained species are desorbed by a laser pulse and analysed by time-of-flight mass spectrometry. Its first name was surface-enhanced affinity capture, as opposed to surface-enhanced neat desorption, in which the coating serves only as a desorption surface.",
  "subject": "Analytical Chemistry",
  "see_also": [
    "laser desorption"
  ],
  "references": [
    "PAC, 2013, 85, 1515. 'Definitions of terms relating to mass spectrometry (IUPAC Recommendations 2013)' on page 1593 (https://doi.org/10.1351/PAC-REC-06-04-06)"
  ],
  "url": "https://mlchart.com/terminology/chemistry/surface-enhanced-laser-desorption-ionization/"
}