Two-generation reprotox study

{
  "id": "MLC-T-CHM-012378",
  "term": "Two-generation reprotox study",
  "field": "Chemistry",
  "definition": "An animal study designed to assess the potential adverse effects of a substance on reproductive function and development over two successive generations. Parental animals (F0 generation) are exposed to the substance before mating and throughout gestation and lactation, and their offspring (F1 generation) are then raised and similarly evaluated for reproductive health. This type of study provides data on fertility, litter size, offspring viability, and developmental abnormalities across generations.",
  "subject": "Chemistry and Human Health",
  "see_also": [
    "F1 generation",
    "one-generation reprotox study"
  ],
  "references": [
    "PAC, 2016, 88, 713. 'Glossary of terms used in developmental and reproductive toxicology (IUPAC Recommendations 2016)' on page 816 (https://doi.org/10.1515/pac-2015-1202)"
  ],
  "url": "https://mlchart.com/terminology/chemistry/two-generation-reprotox-study/"
}