Uronium salts

Term · Chemistry · MLC-T-CHM-012472

Cations formed by protonating urea on oxygen, which gives a carbon bearing one hydroxyl and two amino groups and a positive charge, together with their O- and N-hydrocarbyl derivatives, and the salts of these cations. The name is also applied to coupling reagents such as HBTU and TBTU, which carry an O-substituted tetramethylurea cation. These reagents convert carboxylic acids into active benzotriazolyl esters for amide bond formation in peptide synthesis.

Table 1. Record
Identifier	MLC-T-CHM-012472
Field	Chemistry
Subject	Organic and Biomolecular Chemistry
References	PAC, 1995, 67, 1307. 'Glossary of class names of organic compounds and reactivity intermediates based on structure (IUPAC Recommendations 1995)' on page 1374 (https://doi.org/10.1351/pac199567081307)
See also	Hydrocarbyl groups

Record as JSON

{
  "id": "MLC-T-CHM-012472",
  "term": "Uronium salts",
  "field": "Chemistry",
  "definition": "Cations formed by protonating urea on oxygen, which gives a carbon bearing one hydroxyl and two amino groups and a positive charge, together with their O- and N-hydrocarbyl derivatives, and the salts of these cations. The name is also applied to coupling reagents such as HBTU and TBTU, which carry an O-substituted tetramethylurea cation. These reagents convert carboxylic acids into active benzotriazolyl esters for amide bond formation in peptide synthesis.",
  "subject": "Organic and Biomolecular Chemistry",
  "see_also": [
    "hydrocarbyl groups"
  ],
  "references": [
    "PAC, 1995, 67, 1307. 'Glossary of class names of organic compounds and reactivity intermediates based on structure (IUPAC Recommendations 1995)' on page 1374 (https://doi.org/10.1351/pac199567081307)"
  ],
  "url": "https://mlchart.com/terminology/chemistry/uronium-salts/"
}

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