1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine

{
  "id": "MLC-T-CHM-000008",
  "term": "1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine",
  "field": "Chemistry",
  "definition": "A neurotoxic compound that selectively destroys dopaminergic neurons in the substantia nigra region of the brain. Its toxicity is mediated by its metabolite, MPP+, which is formed by the enzyme monoamine oxidase B and inhibits complex I of the mitochondrial electron transport chain. Because it induces permanent symptoms of Parkinson disease in exposed individuals, it is used in animal models to study the disease's pathology and potential treatments.",
  "subject": "Chemistry and Human Health",
  "see_also": [
    "opioid",
    "Parkinson disease"
  ],
  "references": [
    "PAC, 2015, 87, 841. 'IUPAC Glossary of terms used in neurotoxicology (IUPAC Recommendations 2015)' on page 881 (https://doi.org/10.1515/pac-2015-0103)"
  ],
  "url": "https://mlchart.com/terminology/chemistry/1-methyl-4-phenyl-1236-tetrahydropyridine/"
}