Autoinflammatory disease

{
  "id": "MLC-T-CHM-000986",
  "term": "Autoinflammatory disease",
  "field": "Chemistry",
  "definition": "A condition characterized by recurrent episodes of systemic inflammation, resulting from a dysfunction in the innate immune system without the involvement of autoantibodies or antigen-specific T-lymphocytes. These disorders are caused by genetic mutations in proteins that regulate inflammatory pathways, leading to unprovoked activation of immune cells like neutrophils and macrophages. Familial Mediterranean fever is a classic example of a monogenic autoinflammatory disease.",
  "subject": "Chemistry and Human Health",
  "see_also": [
    "T lymphocyte",
    "autoantibody"
  ],
  "references": [
    "PAC, 2012, 84, 1113. 'IUPAC glossary of terms used in immunotoxicology (IUPAC Recommendations 2012)' on page 1131 (https://doi.org/10.1351/PAC-REC-11-06-03)"
  ],
  "url": "https://mlchart.com/terminology/chemistry/autoinflammatory-disease/"
}