Familial hemophagocytic lymphohistiocytosis

{
  "id": "MLC-T-CHM-004336",
  "term": "Familial hemophagocytic lymphohistiocytosis",
  "field": "Chemistry",
  "definition": "A rare, inherited immune disorder characterized by uncontrolled activation and proliferation of lymphocytes and macrophages, leading to excessive inflammation and tissue damage. This condition results in the destruction of blood cells by activated macrophages, a process known as hemophagocytosis. It is diagnosed by specific clinical and laboratory criteria, including fever, splenomegaly, and cytopenias.",
  "subject": "Chemistry and Human Health",
  "see_also": [
    "CD8+ T suppressor cell",
    "erythrocyte",
    "leukocyte",
    "lymphoid tissue",
    "macrophage",
    "perforin",
    "phagocytosis"
  ],
  "references": [
    "PAC, 2012, 84, 1113. 'IUPAC glossary of terms used in immunotoxicology (IUPAC Recommendations 2012)' on page 1165 (https://doi.org/10.1351/PAC-REC-11-06-03)"
  ],
  "url": "https://mlchart.com/terminology/chemistry/familial-hemophagocytic-lymphohistiocytosis/"
}