Chromium release assay

{
  "id": "MLC-T-CHM-002049",
  "term": "Chromium release assay",
  "field": "Chemistry",
  "definition": "A quantitative method for assessing cell-mediated cytotoxicity, where target cells are pre-loaded with radioactive chromium-51. Upon lysis by cytotoxic immune cells, the intracellular chromium-51 is released into the extracellular medium. The amount of radioactivity detected in the supernatant directly correlates with the extent of cell death.",
  "synonyms": [
    "⁵¹Cr release assay"
  ],
  "subject": "Chemistry and Human Health",
  "see_also": [
    "immunotoxic",
    "chromate uptake assay",
    "cytotoxic T lymphocyte",
    "macrophage",
    "natural killer cell"
  ],
  "references": [
    "PAC, 2012, 84, 1113. 'IUPAC glossary of terms used in immunotoxicology (IUPAC Recommendations 2012)' on page 1143 (https://doi.org/10.1351/PAC-REC-11-06-03)"
  ],
  "url": "https://mlchart.com/terminology/chemistry/chromium-release-assay/"
}