Hinge region

{
  "id": "MLC-T-CHM-005306",
  "term": "Hinge region",
  "field": "Chemistry",
  "definition": "A flexible polypeptide segment within an antibody molecule, located between the Fab and Fc regions of the heavy chains. This region allows for conformational changes and segmental flexibility of the antibody arms, enabling efficient binding to antigens. The length and amino acid composition of the hinge region vary among different immunoglobulin classes.",
  "subject": "Chemistry and Human Health",
  "see_also": [
    "Fab fragment"
  ],
  "references": [
    "PAC, 2012, 84, 1113. 'IUPAC glossary of terms used in immunotoxicology (IUPAC Recommendations 2012)' on page 1176 (https://doi.org/10.1351/PAC-REC-11-06-03)"
  ],
  "url": "https://mlchart.com/terminology/chemistry/hinge-region/"
}