Homocytotropic antibody

{
  "id": "MLC-T-CHM-005356",
  "term": "Homocytotropic antibody",
  "field": "Chemistry",
  "definition": "An antibody that binds to cells of the same species, particularly mast cells and basophils, through its Fc region. This binding sensitizes the cells, leading to the release of inflammatory mediators upon subsequent antigen exposure. Immunoglobulin E (IgE) is a prominent example of a homocytotropic antibody in humans.",
  "subject": "Chemistry and Human Health",
  "see_also": [
    "autologous antibody",
    "heterologous antibody",
    "heterophile antibody"
  ],
  "references": [
    "PAC, 2012, 84, 1113. 'IUPAC glossary of terms used in immunotoxicology (IUPAC Recommendations 2012)' on page 1177 (https://doi.org/10.1351/PAC-REC-11-06-03)"
  ],
  "url": "https://mlchart.com/terminology/chemistry/homocytotropic-antibody/"
}