Intramembrous ossification

{
  "id": "MLC-T-CHM-006012",
  "term": "Intramembrous ossification",
  "field": "Chemistry",
  "definition": "A direct process of bone formation where mesenchymal stem cells differentiate directly into osteoblasts, which then secrete bone matrix without an intermediate cartilage model. This mechanism is responsible for the formation of flat bones of the skull, the mandible, and the clavicles. It involves the aggregation of mesenchymal cells into ossification centers.",
  "subject": "Chemistry and Human Health",
  "see_also": [
    "endochondral ossification",
    "extracellular matrix",
    "fetus",
    "mesenchyme",
    "vertebrate"
  ],
  "references": [
    "PAC, 2016, 88, 713. 'Glossary of terms used in developmental and reproductive toxicology (IUPAC Recommendations 2016)' on page 770 (https://doi.org/10.1515/pac-2015-1202)"
  ],
  "url": "https://mlchart.com/terminology/chemistry/intramembrous-ossification/"
}