Intrinsic pathway

{
  "id": "MLC-T-CHM-006033",
  "term": "Intrinsic pathway",
  "field": "Chemistry",
  "definition": "The mitochondrial route to apoptosis, triggered from inside the cell by stresses such as DNA damage, hypoxia, loss of survival factors, or a defective cell cycle. These signals shift the balance of Bcl-2 family proteins, so that mitochondria release cytochrome c, which assembles the apoptosome and activates caspase-9, in turn activating the executioner caspases 3 and 7. It contrasts with the extrinsic pathway, which starts at death receptors such as Fas and activates caspase-8.",
  "subject": "Chemistry and Human Health",
  "see_also": [
    "extracellular matrix",
    "extrinsic pathway"
  ],
  "references": [
    "PAC, 2016, 88, 713. 'Glossary of terms used in developmental and reproductive toxicology (IUPAC Recommendations 2016)' on page 770 (https://doi.org/10.1515/pac-2015-1202)"
  ],
  "url": "https://mlchart.com/terminology/chemistry/intrinsic-pathway/"
}