Peptide tetramer

{
  "id": "MLC-T-CHM-013380",
  "term": "Peptide tetramer",
  "field": "Chemistry",
  "definition": "A reagent made of four biotinylated peptide-MHC complexes held together by one fluorescently labelled streptavidin molecule, which has four biotin-binding sites. The multivalent complex binds with high avidity to T cell receptors that recognise that peptide presented by that MHC molecule. In flow cytometry, tetramer staining identifies and counts antigen-specific T cells in a blood sample.",
  "subject": "Chemistry and Human Health",
  "see_also": [
    "major histocompatibility complex"
  ],
  "references": [
    "PAC, 2012, 84, 1113. 'IUPAC glossary of terms used in immunotoxicology (IUPAC Recommendations 2012)' on page 1226 (https://doi.org/10.1351/PAC-REC-11-06-03)"
  ],
  "url": "https://mlchart.com/terminology/chemistry/peptide-tetramer/"
}