Second set rejection

{
  "id": "MLC-T-CHM-010608",
  "term": "Second set rejection",
  "field": "Chemistry",
  "definition": "A phenomenon observed in transplantation immunology where a second graft from the same donor, or a donor sharing major histocompatibility complex (MHC) antigens, is rejected much more rapidly and vigorously than the first graft. This accelerated rejection is due to the presence of pre-existing memory T cells and antibodies generated during the initial exposure to the donor antigens. It demonstrates immunological memory.",
  "subject": "Chemistry and Human Health",
  "see_also": [
    "allograft",
    "prime",
    "rejection"
  ],
  "references": [
    "PAC, 2012, 84, 1113. 'IUPAC glossary of terms used in immunotoxicology (IUPAC Recommendations 2012)' on page 1242 (https://doi.org/10.1351/PAC-REC-11-06-03)"
  ],
  "url": "https://mlchart.com/terminology/chemistry/second-set-rejection/"
}