Thyroid-stimulating hormone receptor

{
  "id": "MLC-T-CHM-012053",
  "term": "Thyroid-stimulating hormone receptor",
  "field": "Chemistry",
  "definition": "A cell surface protein found primarily on thyroid follicular cells that binds thyroid-stimulating hormone (TSH), initiating a signaling cascade that regulates thyroid hormone production and release. Autoantibodies targeting this receptor can either stimulate or block its function, leading to thyroid dysfunction. In Graves' disease, stimulating autoantibodies cause hyperthyroidism by mimicking TSH action.",
  "subject": "Chemistry and Human Health",
  "see_also": [
    "Graves disease",
    "autoantibody",
    "autoantigen"
  ],
  "references": [
    "PAC, 2012, 84, 1113. 'IUPAC glossary of terms used in immunotoxicology (IUPAC Recommendations 2012)' on page 1253 (https://doi.org/10.1351/PAC-REC-11-06-03)"
  ],
  "url": "https://mlchart.com/terminology/chemistry/thyroid-stimulating-hormone-receptor/"
}