Tissue transglutaminase

{
  "id": "MLC-T-CHM-012084",
  "term": "Tissue transglutaminase",
  "field": "Chemistry",
  "definition": "An enzyme that catalyzes the formation of isopeptide bonds between protein-bound glutamine and lysine residues, leading to protein cross-linking. In immunology, autoantibodies targeting this enzyme are a primary diagnostic marker for celiac disease, an autoimmune disorder triggered by gluten. The detection of IgA antibodies against tissue transglutaminase is a standard serological test for screening individuals for this condition.",
  "subject": "Chemistry and Human Health",
  "see_also": [
    "autoantibody",
    "celiac disease"
  ],
  "references": [
    "PAC, 2012, 84, 1113. 'IUPAC glossary of terms used in immunotoxicology (IUPAC Recommendations 2012)' on page 1254 (https://doi.org/10.1351/PAC-REC-11-06-03)"
  ],
  "url": "https://mlchart.com/terminology/chemistry/tissue-transglutaminase/"
}