Mixed connective tissue disease

{
  "id": "MLC-T-CHM-007422",
  "term": "Mixed connective tissue disease",
  "field": "Chemistry",
  "definition": "A systemic autoimmune disorder characterized by features of several connective tissue diseases, including systemic lupus erythematosus, scleroderma, and polymyositis. Patients with this condition typically exhibit high titers of autoantibodies against U1 small nuclear ribonucleoprotein (U1-snRNP). Diagnosis relies on a combination of clinical symptoms and specific serological markers.",
  "synonyms": [
    "Sharp’s syndrome"
  ],
  "subject": "Chemistry and Human Health",
  "see_also": [
    "Raynaud phenomenon",
    "antinuclear antibody",
    "autoimmune disease",
    "immune system",
    "scleroderma",
    "systemic",
    "systemic lupus erythematosus"
  ],
  "references": [
    "PAC, 2012, 84, 1113. 'IUPAC glossary of terms used in immunotoxicology (IUPAC Recommendations 2012)' on page 1213 (https://doi.org/10.1351/PAC-REC-11-06-03)"
  ],
  "url": "https://mlchart.com/terminology/chemistry/mixed-connective-tissue-disease/"
}