Glutamate-induced excitotoxicity

{
  "id": "MLC-T-CHM-004927",
  "term": "Glutamate-induced excitotoxicity",
  "field": "Chemistry",
  "definition": "Neuronal damage or death caused by excessive or prolonged activation of glutamate receptors, particularly N-methyl-D-aspartate (NMDA) receptors. This overstimulation leads to an influx of calcium ions into neurons, triggering a cascade of destructive biochemical events. It is implicated in acute brain injuries like stroke and in neurodegenerative diseases.",
  "subject": "Chemistry and Human Health",
  "see_also": [
    "N-methyl-D-aspartate",
    "excitotoxicity",
    "glutamate",
    "kainic acid",
    "nervous system",
    "synapse",
    "withdrawal"
  ],
  "references": [
    "PAC, 2015, 87, 841. 'IUPAC Glossary of terms used in neurotoxicology (IUPAC Recommendations 2015)' on page 871 (https://doi.org/10.1515/pac-2015-0103)"
  ],
  "url": "https://mlchart.com/terminology/chemistry/glutamate-induced-excitotoxicity/"
}