Glutamic acid decarboxylase

{
  "id": "MLC-T-CHM-004928",
  "term": "Glutamic acid decarboxylase",
  "field": "Chemistry",
  "definition": "An enzyme that catalyzes the decarboxylation of glutamic acid to form gamma-aminobutyric acid (GABA), the primary inhibitory neurotransmitter in the central nervous system. This enzyme exists in two isoforms, GAD65 and GAD67, which are encoded by different genes. Autoantibodies against glutamic acid decarboxylase are a biomarker for Type 1 diabetes and some neurological disorders.",
  "subject": "Chemistry and Human Health",
  "see_also": [
    "autoantigen",
    "autoimmune disease",
    "diabetes mellitus type 1"
  ],
  "references": [
    "PAC, 2012, 84, 1113. 'IUPAC glossary of terms used in immunotoxicology (IUPAC Recommendations 2012)' on page 1170 (https://doi.org/10.1351/PAC-REC-11-06-03)"
  ],
  "url": "https://mlchart.com/terminology/chemistry/glutamic-acid-decarboxylase/"
}