Non-ideal, non-linear chromatography

{
  "id": "MLC-T-CHM-008027",
  "term": "Non-ideal, non-linear chromatography",
  "field": "Chemistry",
  "definition": "A chromatographic separation characterized by both non-ideal kinetic effects and non-linear adsorption isotherms, leading to complex peak shapes and retention behavior. The non-linear isotherms cause concentration-dependent retention, while non-ideal kinetics contribute to peak broadening and asymmetry. This type of chromatography is observed when solute concentrations are high or when mass transfer limitations are present.",
  "subject": "Analytical Chemistry",
  "see_also": [
    "diffusion",
    "fronting",
    "tailing"
  ],
  "references": [
    "PAC, 1996, 68, 1591. 'Nomenclature for non-linear chromatography (IUPAC Recommendations 1996)' on page 1594 (https://doi.org/10.1351/pac199668081591)"
  ],
  "url": "https://mlchart.com/terminology/chemistry/non-ideal-non-linear-chromatography/"
}