Very late activation antigen

{
  "id": "MLC-T-CHM-012556",
  "term": "Very late activation antigen",
  "field": "Chemistry",
  "definition": "A member of the integrin family of cell adhesion molecules, expressed on the surface of T lymphocytes and other leukocytes several days after initial activation. These heterodimeric proteins, such as VLA-4, mediate cell-to-cell and cell-to-extracellular matrix interactions, which are involved in lymphocyte trafficking and inflammatory responses. The VLA family is a subgroup of the β1 integrins, all sharing a common β1 subunit paired with a distinct α subunit.",
  "subject": "Chemistry and Human Health",
  "see_also": [
    "T lymphocyte",
    "superfamily"
  ],
  "references": [
    "PAC, 2012, 84, 1113. 'IUPAC glossary of terms used in immunotoxicology (IUPAC Recommendations 2012)' on page 1259 (https://doi.org/10.1351/PAC-REC-11-06-03)"
  ],
  "url": "https://mlchart.com/terminology/chemistry/very-late-activation-antigen/"
}