Denaturation

{
  "id": "MLC-T-CHM-002985",
  "term": "Denaturation",
  "field": "Chemistry",
  "definition": "The process by which the characteristic three-dimensional structure of a macromolecule, such as a protein or nucleic acid, is altered from its native state. This alteration results in the loss of its biological activity. Denaturation can be induced by heat, extreme pH, organic solvents, or strong detergents, disrupting non-covalent bonds.",
  "subject": "Chemistry and the Environment",
  "see_also": [
    "nucleic acids",
    "proteins",
    "salt",
    "secondary structure"
  ],
  "references": [
    "PAC, 1992, 64, 143. 'Glossary for chemists of terms used in biotechnology (IUPAC Recommendations 1992)' on page 151 (https://doi.org/10.1351/pac199264010143)",
    "PAC, 1994, 66, 2587. 'Glossary of bioanalytical nomenclature - Part 1: General terminology, body fluids, enzymology, immunology (IUPAC Recommendations 1994)' on page 2593 (https://doi.org/10.1351/pac199466122587)",
    "PAC, 1993, 65, 2003. 'Glossary for chemists of terms used in toxicology (IUPAC Recommendations 1993)' on page 2036 (https://doi.org/10.1351/pac199365092003)"
  ],
  "url": "https://mlchart.com/terminology/chemistry/denaturation/"
}