Leukotriene

{
  "id": "MLC-T-CHM-006538",
  "term": "Leukotriene",
  "field": "Chemistry",
  "definitions": [
    "A class of eicosanoid inflammatory mediators derived from arachidonic acid through the action of the enzyme 5-lipoxygenase. These lipid compounds are produced by leukocytes and other immune cells, contributing to allergic reactions and inflammatory responses. Leukotrienes are potent bronchoconstrictors and increase vascular permeability, playing a role in asthma and anaphylaxis.",
    "A family of icosanoid lipid mediators derived from the enzymatic oxidation of arachidonic acid and other polyunsaturated fatty acids. Their structure contains a characteristic conjugated triene system, from which their name is derived. Leukotrienes are synthesized in the body by the 5-lipoxygenase pathway and are involved in mediating inflammatory and allergic responses, such as bronchoconstriction in asthma and leukocyte chemotaxis."
  ],
  "subject": [
    "Chemistry and Human Health",
    "Organic and Biomolecular Chemistry"
  ],
  "see_also": [
    "basophil",
    "chemotaxis",
    "macrophage",
    "mast cell",
    "icosanoids"
  ],
  "references": [
    "PAC, 2012, 84, 1113. 'IUPAC glossary of terms used in immunotoxicology (IUPAC Recommendations 2012)' on page 1202 (https://doi.org/10.1351/PAC-REC-11-06-03)",
    "PAC, 1995, 67, 1307. 'Glossary of class names of organic compounds and reactivity intermediates based on structure (IUPAC Recommendations 1995)' on page 1347 (https://doi.org/10.1351/pac199567081307)"
  ],
  "url": "https://mlchart.com/terminology/chemistry/leukotriene/"
}