Epithelial-to-mesenchymal transition

{
  "id": "MLC-T-CHM-004039",
  "term": "Epithelial-to-mesenchymal transition",
  "field": "Chemistry",
  "definition": "A biological process in which polarized epithelial cells, which are normally bound together in a sheet, undergo biochemical changes to assume a mesenchymal cell phenotype. This transformation involves a loss of cell-to-cell adhesion and apical-basal polarity, accompanied by an increase in migratory and invasive capabilities. The process is a normal part of embryonic development and also occurs in wound healing and cancer metastasis.",
  "subject": "Chemistry and Human Health",
  "see_also": [
    "cancer",
    "embryogenesis",
    "epithelium",
    "mesenchyme",
    "mesenchymal-to-epithelial transition"
  ],
  "references": [
    "PAC, 2016, 88, 713. 'Glossary of terms used in developmental and reproductive toxicology (IUPAC Recommendations 2016)' on page 750 (https://doi.org/10.1515/pac-2015-1202)"
  ],
  "url": "https://mlchart.com/terminology/chemistry/epithelial-to-mesenchymal-transition/"
}