Fetal tolerance

{
  "id": "MLC-T-CHM-013099",
  "term": "Fetal tolerance",
  "field": "Chemistry",
  "definition": "The immunological state that prevents the maternal immune system from mounting a destructive response against the semi-allogeneic fetus. This complex process involves multiple mechanisms, including the generation of regulatory T cells and the unique expression of human leukocyte antigen (HLA) molecules at the maternal-fetal interface. A breakdown in these tolerance mechanisms is implicated in pregnancy complications like pre-eclampsia and recurrent spontaneous abortion.",
  "subject": "Chemistry and Human Health",
  "see_also": [
    "allograft",
    "major histocompatibility complex",
    "minor histocompatibility antigen",
    "rejection"
  ],
  "references": [
    "PAC, 2012, 84, 1113. 'IUPAC glossary of terms used in immunotoxicology (IUPAC Recommendations 2012)' on page 1166 (https://doi.org/10.1351/PAC-REC-11-06-03)"
  ],
  "url": "https://mlchart.com/terminology/chemistry/fetal-tolerance/"
}