General acid catalysis

{
  "id": "MLC-T-CHM-004817",
  "term": "General acid catalysis",
  "field": "Chemistry",
  "definition": "A catalysis in which the rate in solution depends on the concentration of every Brønsted acid present, not only the solvated proton, so the catalyzed rate is a sum of terms, each the product of one acid's catalytic constant and its concentration. The proton is transferred from the acid to the substrate in the rate-determining step. For a related series of acids the catalytic constants follow the Brønsted relation, in which log k falls linearly as pKa rises, with a slope alpha between 0 and 1.",
  "subject": "Organic and Biomolecular Chemistry",
  "see_also": [
    "Brønsted acid",
    "catalysis",
    "catalytic coefficient",
    "hydron",
    "intramolecular catalysis",
    "pseudo-catalysis",
    "rate of reaction",
    "specific catalysis",
    "substrate"
  ],
  "references": [
    "PAC, 1994, 66, 1077. 'Glossary of terms used in physical organic chemistry (IUPAC Recommendations 1994)' on page 1117 (https://doi.org/10.1351/pac199466051077)"
  ],
  "url": "https://mlchart.com/terminology/chemistry/general-acid-catalysis/"
}