Nucleophilic catalysis

Term · Chemistry · MLC-T-CHM-013351

A form of catalysis where a nucleophile, the catalyst, reacts with a substrate to form a reactive intermediate, which is more susceptible to subsequent reaction than the original substrate. The catalyst is regenerated in a later step of the reaction sequence. This mechanism is distinct from general base catalysis, where the catalyst removes a proton from the substrate in the rate-determining step.

Table 1. Record
Identifier	MLC-T-CHM-013351
Field	Chemistry
Subject	Organic and Biomolecular Chemistry
References	PAC, 1994, 66, 1077. 'Glossary of terms used in physical organic chemistry (IUPAC Recommendations 1994)' on page 1146 (https://doi.org/10.1351/pac199466051077)
See also	Catalysis; Lewis adduct; Lewis base; Electrophile; Hydrolysis; Nucleophilicity

Record as JSON

{
  "id": "MLC-T-CHM-013351",
  "term": "Nucleophilic catalysis",
  "field": "Chemistry",
  "definition": "A form of catalysis where a nucleophile, the catalyst, reacts with a substrate to form a reactive intermediate, which is more susceptible to subsequent reaction than the original substrate. The catalyst is regenerated in a later step of the reaction sequence. This mechanism is distinct from general base catalysis, where the catalyst removes a proton from the substrate in the rate-determining step.",
  "subject": "Organic and Biomolecular Chemistry",
  "see_also": [
    "catalysis",
    "Lewis adduct",
    "Lewis base",
    "electrophile",
    "hydrolysis",
    "nucleophilicity"
  ],
  "references": [
    "PAC, 1994, 66, 1077. 'Glossary of terms used in physical organic chemistry (IUPAC Recommendations 1994)' on page 1146 (https://doi.org/10.1351/pac199466051077)"
  ],
  "url": "https://mlchart.com/terminology/chemistry/nucleophilic-catalysis/"
}

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