Gell and Coombs classification

{
  "id": "MLC-T-CHM-004801",
  "term": "Gell and Coombs classification",
  "field": "Chemistry",
  "definition": "A system for categorizing hypersensitivity reactions into four main types based on the immunological mechanisms involved. Type I involves IgE-mediated mast cell degranulation, Type II involves antibody-mediated cytotoxicity, Type III involves immune complex deposition, and Type IV is a T-cell mediated delayed-type hypersensitivity. This classification provides a framework for understanding and diagnosing allergic and autoimmune responses.",
  "subject": "Chemistry and Human Health",
  "see_also": [
    "T lymphocyte",
    "cytotoxic T lymphocyte",
    "hypersensitivity",
    "immediate-type hypersensitivity",
    "immune complex",
    "immunoglobulin E",
    "lymphokine"
  ],
  "references": [
    "PAC, 2012, 84, 1113. 'IUPAC glossary of terms used in immunotoxicology (IUPAC Recommendations 2012)' on page 1168 (https://doi.org/10.1351/PAC-REC-11-06-03)"
  ],
  "url": "https://mlchart.com/terminology/chemistry/gell-and-coombs-classification/"
}